sodium lauryl sulfate (avoidance)
Place in Therapy
Sodium lauryl sulfate (SLS) is a detergent commonly found in commercially-available toothpastes.
Studies investigating the relationship between SLS and aphthous ulcers have specifically looked at the effects of SLS-containing toothpastes among patients suffering from recurrent aphthous ulcers (no other product
types) (1)(8)(9)(10).
To date, clinical trials have concluded that the use of SLS-containing toothpastes increases the frequency, number and severity (i.e.pain) of oral ulcers in this specific patient population (8)(9)(10). There was however one trial that indicated there was no significant difference between SLS-containing versus SLS-free toothpastes with respect to aphthous ulcer
presentation(10). It is important to note that no studies have specifically examined the effects of SLS in specific patient populations i.e. pregnant women, children, elderly, etc. In weighing the current evidence, patients with recurrent aphthous ulcers should thus be advised to avoid SLS-containing toothpastes given its associated aggravating effects (8)(9).
References:
1. Shim YJ, Choi JH, Ahn HJ, Kwon JS. Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a randomized controlled clinical trial. Oral Dis. 2012;18:655-60.
2. Herlofson BB, Barkvoll P. The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996;54:150-3.
3. Chahine L, Sempson N, Wagoner C. he effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend. 1997;18(12):1238-40.
4. Healy CM, Paterson M, Joyston-Bechal S, Williams DM, Thornhill MH. The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration. Oral Dis. 1999;5:39-43.
5. Micromedex 2.0. AltMedDex® Protocols: Canker Sores [Internet]. Truven Health Analytics Inc. [cited 2013 Jul 08].
Available from: http://www.micromedexsolutions.com/micromedex2/librarian/ND_T/evidencexpert/ND_PR/evidencexpert/CS/4AEC81/ND_AppProduct/evidencexpert/DUPLICATIONSHIELDSYNC/38362E/ND_PG/evidencexpert/ND_B/evidencexpert/ND_P/evidencexpert/PFActionId/evidencexpert.IntermediateToDocumentLink?docId=30&contentSetId=75&title=CANKER+SORES&servicesTitle=CANKER+SORES
6. Goldstein BG, Goldstein AO. Oral Lesions [Internet]. Dellavalle RP, Deschler DG, editors. UpToDate Inc. [updated 2012 Aug 17; cited 2013 Jul 08]. Available from:
www.uptodate.com/contents/oral-lesions?source=preview&anchor+H757722&selectedTitle=3~6#H7432083
7. Goldstein BG, Goldstein AO. Oral Lesions [Internet]. Dellavalle RP, Deschler DG, editors. UpToDate Inc. [updated 2012 Aug 17; cited 2013 Jul 08]. Available from: www.uptodate.com/contents/oral-lesions?source=preview&anchor+H757722&selectedTitle=3~6#H7432083
8. Herlofson BB, Barkvoll P. The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996;54:150-3.
9. Chahine L, Sempson N, Wagoner C. he effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend. 1997;18(12):1238-40.
10. Healy CM, Paterson M, Joyston-Bechal S, Williams DM, Thornhill MH. The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration. Oral Dis. 1999;5:39-43.
11. Gerstein J. The truth about natural toothpaste [internet]. The Daily Green. [Cited: 2013 Jul 11] Available from: http://www.thedailygreen.com/living-green/natural-toothpaste-ingredients-0307.
Studies investigating the relationship between SLS and aphthous ulcers have specifically looked at the effects of SLS-containing toothpastes among patients suffering from recurrent aphthous ulcers (no other product
types) (1)(8)(9)(10).
To date, clinical trials have concluded that the use of SLS-containing toothpastes increases the frequency, number and severity (i.e.pain) of oral ulcers in this specific patient population (8)(9)(10). There was however one trial that indicated there was no significant difference between SLS-containing versus SLS-free toothpastes with respect to aphthous ulcer
presentation(10). It is important to note that no studies have specifically examined the effects of SLS in specific patient populations i.e. pregnant women, children, elderly, etc. In weighing the current evidence, patients with recurrent aphthous ulcers should thus be advised to avoid SLS-containing toothpastes given its associated aggravating effects (8)(9).
References:
1. Shim YJ, Choi JH, Ahn HJ, Kwon JS. Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a randomized controlled clinical trial. Oral Dis. 2012;18:655-60.
2. Herlofson BB, Barkvoll P. The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996;54:150-3.
3. Chahine L, Sempson N, Wagoner C. he effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend. 1997;18(12):1238-40.
4. Healy CM, Paterson M, Joyston-Bechal S, Williams DM, Thornhill MH. The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration. Oral Dis. 1999;5:39-43.
5. Micromedex 2.0. AltMedDex® Protocols: Canker Sores [Internet]. Truven Health Analytics Inc. [cited 2013 Jul 08].
Available from: http://www.micromedexsolutions.com/micromedex2/librarian/ND_T/evidencexpert/ND_PR/evidencexpert/CS/4AEC81/ND_AppProduct/evidencexpert/DUPLICATIONSHIELDSYNC/38362E/ND_PG/evidencexpert/ND_B/evidencexpert/ND_P/evidencexpert/PFActionId/evidencexpert.IntermediateToDocumentLink?docId=30&contentSetId=75&title=CANKER+SORES&servicesTitle=CANKER+SORES
6. Goldstein BG, Goldstein AO. Oral Lesions [Internet]. Dellavalle RP, Deschler DG, editors. UpToDate Inc. [updated 2012 Aug 17; cited 2013 Jul 08]. Available from:
www.uptodate.com/contents/oral-lesions?source=preview&anchor+H757722&selectedTitle=3~6#H7432083
7. Goldstein BG, Goldstein AO. Oral Lesions [Internet]. Dellavalle RP, Deschler DG, editors. UpToDate Inc. [updated 2012 Aug 17; cited 2013 Jul 08]. Available from: www.uptodate.com/contents/oral-lesions?source=preview&anchor+H757722&selectedTitle=3~6#H7432083
8. Herlofson BB, Barkvoll P. The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996;54:150-3.
9. Chahine L, Sempson N, Wagoner C. he effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend. 1997;18(12):1238-40.
10. Healy CM, Paterson M, Joyston-Bechal S, Williams DM, Thornhill MH. The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration. Oral Dis. 1999;5:39-43.
11. Gerstein J. The truth about natural toothpaste [internet]. The Daily Green. [Cited: 2013 Jul 11] Available from: http://www.thedailygreen.com/living-green/natural-toothpaste-ingredients-0307.