BISMUTH SUBSALICYLATE
Place in Therapy
Place in Therapy
There is only one primary literature article available for BSS and all other references which mention the use of BSS reference this article.1 This article assessed in vitro and in vivo actions of BSS on hydrogen sulphide gas production in ten healthy volunteers.1 Each volunteer had feces sample collected prior to the study and then after 3 days of treatment. Some patients continued to take BSS for a total of 7 days. 1 It was found that BSS completely bound H2S within hours of taking 524mg of BSS with a meal.1
BSS should be used by patients that have malodourous gas.1 Its use should be restricted to less than 3 weeks as it can be associated with salicylate3 toxicity. Patient should incorporate appropriate lifestyle management and undergo a full work up to determine the cause of the malodours flatulence.4 When counseling a patient, it is important to explain that while they may have a normal level of gas they may actually be more sensitive to this feeling.4
References
1. Suarez FL, Furne JK, Springfield J, Levitt MD. Bismuth subsalicylate markedly decreases hydrogen sulphide release in the human colon. American Gastroenterological Association. 1998; 114(5):923-929.
2. Suarez FL, Levitt MD. An understanding of excessive intestinal gas. Current Gastroenterology Reports. 2000; 2:413-419.
3. CO Q.D. Chapter 34: Gastrointestinal Gas. Self Care 2010. Canadian Pharmacists Association. Second edition. Webcom Inc. Toronto.
4. Jones MP. Bloating and Intestinal Gas. Current Treatment Options in Gastroenterology. 2005; 8:311-318.
5. Abraczinskas D, Goldfinger SE, Talley NJ, and Grover S. Intestinal gas and bloating. UpToDate. 2012. Retrieved online on July 3, 2012 from http://www.uptodate.com/contents/gas-and-bloating-beyond-the-basics.
.
There is only one primary literature article available for BSS and all other references which mention the use of BSS reference this article.1 This article assessed in vitro and in vivo actions of BSS on hydrogen sulphide gas production in ten healthy volunteers.1 Each volunteer had feces sample collected prior to the study and then after 3 days of treatment. Some patients continued to take BSS for a total of 7 days. 1 It was found that BSS completely bound H2S within hours of taking 524mg of BSS with a meal.1
BSS should be used by patients that have malodourous gas.1 Its use should be restricted to less than 3 weeks as it can be associated with salicylate3 toxicity. Patient should incorporate appropriate lifestyle management and undergo a full work up to determine the cause of the malodours flatulence.4 When counseling a patient, it is important to explain that while they may have a normal level of gas they may actually be more sensitive to this feeling.4
References
1. Suarez FL, Furne JK, Springfield J, Levitt MD. Bismuth subsalicylate markedly decreases hydrogen sulphide release in the human colon. American Gastroenterological Association. 1998; 114(5):923-929.
2. Suarez FL, Levitt MD. An understanding of excessive intestinal gas. Current Gastroenterology Reports. 2000; 2:413-419.
3. CO Q.D. Chapter 34: Gastrointestinal Gas. Self Care 2010. Canadian Pharmacists Association. Second edition. Webcom Inc. Toronto.
4. Jones MP. Bloating and Intestinal Gas. Current Treatment Options in Gastroenterology. 2005; 8:311-318.
5. Abraczinskas D, Goldfinger SE, Talley NJ, and Grover S. Intestinal gas and bloating. UpToDate. 2012. Retrieved online on July 3, 2012 from http://www.uptodate.com/contents/gas-and-bloating-beyond-the-basics.
.