vitamin b6
Place in Therapy
Place in Therapy
Studies evaluating the use of vitamin B6 in the treatment of PMS symptoms have had conflicting results.1-5 Systematic reviews have found that vitamin B6 is possibly effective in the reduction of PMS symptoms, particularly those related to mood.3-5 However, studies showing positive results are limited by poor quality and are insufficient to draw definitive conclusions.3,4 Patients seeking relief of PMS symptoms should try therapeutic options with more established evidence prior to seeking out vitamin B6. If patients want to take vitamin B6 despite the lack of clear evidence, doses of 100 mg/day appear to be safe and may improve the mood symptoms of PMS.3 Although some studies have shown benefit in doses exceeding 100 mg/day, doses above this amount may cause peripheral neuropathy should not be recommended.3
References:
1. Kashanian M, Mazinani R, Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet. 2007 Jan;96(1):43-44.
2. Diegoliu MS, da Fonseca AM, Diegoli CA, Pinotti JA. A double-blind trial of four medications to treat severe premenstrual syndrome. Int J Gynaecol Obstet. 1998 July;62(1):63-7.
3. Whelan AM, Jurgens TM, Naylor H. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Can J Clin Pharmacol. 2009 Fall;16(3):e407-29. Epub 2009 Oct 29.
4. Premenstrual syndrome. In: DISEASEDEX™ - General Medicine [Internet database]. Greenwood Village, Colo: Thomson Reuters (Healthcare) Inc. Updated June 20, 2013.
5. Mulherin K, Brown T. Premenstrual syndrome. In: Repchinsky C, ed. Patient self-care. 2nd ed. Ottawa, ON: Canadian Pharmacists Association; 2010:782-791.
Studies evaluating the use of vitamin B6 in the treatment of PMS symptoms have had conflicting results.1-5 Systematic reviews have found that vitamin B6 is possibly effective in the reduction of PMS symptoms, particularly those related to mood.3-5 However, studies showing positive results are limited by poor quality and are insufficient to draw definitive conclusions.3,4 Patients seeking relief of PMS symptoms should try therapeutic options with more established evidence prior to seeking out vitamin B6. If patients want to take vitamin B6 despite the lack of clear evidence, doses of 100 mg/day appear to be safe and may improve the mood symptoms of PMS.3 Although some studies have shown benefit in doses exceeding 100 mg/day, doses above this amount may cause peripheral neuropathy should not be recommended.3
References:
1. Kashanian M, Mazinani R, Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet. 2007 Jan;96(1):43-44.
2. Diegoliu MS, da Fonseca AM, Diegoli CA, Pinotti JA. A double-blind trial of four medications to treat severe premenstrual syndrome. Int J Gynaecol Obstet. 1998 July;62(1):63-7.
3. Whelan AM, Jurgens TM, Naylor H. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Can J Clin Pharmacol. 2009 Fall;16(3):e407-29. Epub 2009 Oct 29.
4. Premenstrual syndrome. In: DISEASEDEX™ - General Medicine [Internet database]. Greenwood Village, Colo: Thomson Reuters (Healthcare) Inc. Updated June 20, 2013.
5. Mulherin K, Brown T. Premenstrual syndrome. In: Repchinsky C, ed. Patient self-care. 2nd ed. Ottawa, ON: Canadian Pharmacists Association; 2010:782-791.