DOCUSATE
Place In Therapy
Overall,
there is no reliable, moderate quality evidence available to recommend
docusate in the treatment of chronic constipation. The available evidence is sparse, heterogeneous
and from small, poorly designed trials.
Even in the trials available, docusate’s benefit has proven modest to
nil. There were no major adverse
effects, drug interactions or safety concerns with the drug at all. There is no evidence supporting its use in
pregnant or lactating women (Category C).
It does enter the systemic circulation, does cross the placenta and
does cross into breast milk.
In conclusion, there is no place for docusate in chronic constipation therapy.
References
1. Lexi-Comp Inc. (2012). Retrieved 2012, from Lexi-Comp Online: http://online.lexi.com.proxy.lib.uwaterloo.ca/crlsql/servlet/crlonline
2. Canadian Pharmacists Association . (2002). Patient Self-Care: Helping patients make therapeutic choices. Ottawa: CPhA.
3. Ministry of Health and Long Term Care. (2012, 01 01). Ontario Drug Benefit Formulary/Comparative Drug Index. Retrieved 03 09, 2012, from Ministry of Health and Long Term Care Website: https://www.healthinfo.moh.gov.on.ca/formulary/index.jsp
4. Mcrorie, J., Daggy, P., Morel, J., Diersing, P., Miner, P., & Robinson, M. (1998). Psyllium is superior to docusate sodium for treatment of chronic constipation. Ailment Pharmacol Ther , 491-497.
5. Goodman, J., Pang, J., & Bessman, A. (1976). Dioctyl Sodium Sulfosuccinate- An Ineffective Prophylactic Laxative. J Chron Dis , 29, 59-63.
6. American College of Gastroenterology Chronic Constipation Task Force. (2005). An Evidence-Based Approace to the Management of Chronic Constipation in North America. American Journal of Gastroenterology , S1-S22.
7. Hurdon, V., Viola, R., & Schroder, C. (2000). How Useful is Docusate in Patients at Risk for Constipation? A Systematic Review of the Evidence in the Chronically Ill. Journal of Pain and Symptom Management , 130-136.
8. Ramkumar, D., & Rao, S. (2005). Efficacy and Safety of Traditional Medical Therapies for Chronic Constipation: Systematic Review. Americn Journal of Gastroenterology , 936-971.
In conclusion, there is no place for docusate in chronic constipation therapy.
References
1. Lexi-Comp Inc. (2012). Retrieved 2012, from Lexi-Comp Online: http://online.lexi.com.proxy.lib.uwaterloo.ca/crlsql/servlet/crlonline
2. Canadian Pharmacists Association . (2002). Patient Self-Care: Helping patients make therapeutic choices. Ottawa: CPhA.
3. Ministry of Health and Long Term Care. (2012, 01 01). Ontario Drug Benefit Formulary/Comparative Drug Index. Retrieved 03 09, 2012, from Ministry of Health and Long Term Care Website: https://www.healthinfo.moh.gov.on.ca/formulary/index.jsp
4. Mcrorie, J., Daggy, P., Morel, J., Diersing, P., Miner, P., & Robinson, M. (1998). Psyllium is superior to docusate sodium for treatment of chronic constipation. Ailment Pharmacol Ther , 491-497.
5. Goodman, J., Pang, J., & Bessman, A. (1976). Dioctyl Sodium Sulfosuccinate- An Ineffective Prophylactic Laxative. J Chron Dis , 29, 59-63.
6. American College of Gastroenterology Chronic Constipation Task Force. (2005). An Evidence-Based Approace to the Management of Chronic Constipation in North America. American Journal of Gastroenterology , S1-S22.
7. Hurdon, V., Viola, R., & Schroder, C. (2000). How Useful is Docusate in Patients at Risk for Constipation? A Systematic Review of the Evidence in the Chronically Ill. Journal of Pain and Symptom Management , 130-136.
8. Ramkumar, D., & Rao, S. (2005). Efficacy and Safety of Traditional Medical Therapies for Chronic Constipation: Systematic Review. Americn Journal of Gastroenterology , 936-971.