Bloodroot
Place in Therapy
Place in Therapy
Sanguinaria canadensis has been hypothesized to reduce plaque and inflammation in gingivitis.
Clinical trials on the efficacy of bloodroot (sanguinaria canadensis) are conflicting and conclusive evidence is lacking. Studies have also shown that bloodroot containing products are inferior to other products available for the treatment and prevention of gingivitis. In 2003, the FDA Dental Plaque subcommittee for non-prescription drug advisory concluded that due to differences in study design, concentration of Sanguinaria Canadensis and formulations of products, controls and statistical analysis, they cannot at this time approve its use in anti-gingivitis and anti-plaque products for over-the-counter use.
There are also safety concerns that with the use of Sanguinaria Canadensis, it may cause leukoplakia and oral dysplastic lesions. Most studies had duration of treatment of approximately six months and perhaps long-term studies need to be conducted in order to determine adverse effects with the use of this product.
References:
1. Cullinan MP, Powell RN, Faddy MJ, Seymore GJ. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Australian Dental Jounral. 1997; 42(1): 47-51.
2. Hanna JJ, Johnson JD, Kuftinec MM. Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation and sulcular bleeding during orthodontic treatment. Am J. Ortho Dentofac Orthop. 1989; 96(3): 199-207.
3. Vlachojannis C, Magora F, Chrubasik S. Review: Rise and fall of oral health products with Canadian bloodroot extract. Phytother Res. 2012: 26: 1423-1426.
4. Bloodroot (Sanguinaria canadensis). In: Natural Standard [Internet Database]. Somerville, MA: Natural Standard. Updated Periodically. Retrieved on July 3, 2013 from: http://www.naturalstandard.com.proxy.lib.uwaterloo.ca/databases/herbssupplements/bloodroot.asp?
5. Bloodroot IN: Micromedex 2.0 [Internet Resource]. Last update 2002. Retrieved on July 3, 2013 from: http://www.micromedexsolutions.com/micromedex2/librarian/ND_T/evidencexpert/ND_PR/evidencexpert/CS/FA0CE7/ND_AppProduct/evidencexpert/DUPLICATIONSHIELDSYNC/B49BD0/ND_PG/evidencexpert/ND_B/evidencexpert/ND_P/evidencexpert/PFActionId/evidencexpert.DisplayAltMedEvalDocument?docId=113&contentSetId=60&title=BLOODROOT&servicesTitle=BLOODROOT
6. Bloodroot (Natural Products Database) In: Lexicomp [Internet Resource]. Retrieved on July 3, 2013 from http://online.lexi.com.proxy.lib.uwaterloo.ca/lco/action/doc/retrieve/docid/fc_rnp2/3750055
Sanguinaria canadensis has been hypothesized to reduce plaque and inflammation in gingivitis.
Clinical trials on the efficacy of bloodroot (sanguinaria canadensis) are conflicting and conclusive evidence is lacking. Studies have also shown that bloodroot containing products are inferior to other products available for the treatment and prevention of gingivitis. In 2003, the FDA Dental Plaque subcommittee for non-prescription drug advisory concluded that due to differences in study design, concentration of Sanguinaria Canadensis and formulations of products, controls and statistical analysis, they cannot at this time approve its use in anti-gingivitis and anti-plaque products for over-the-counter use.
There are also safety concerns that with the use of Sanguinaria Canadensis, it may cause leukoplakia and oral dysplastic lesions. Most studies had duration of treatment of approximately six months and perhaps long-term studies need to be conducted in order to determine adverse effects with the use of this product.
References:
1. Cullinan MP, Powell RN, Faddy MJ, Seymore GJ. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Australian Dental Jounral. 1997; 42(1): 47-51.
2. Hanna JJ, Johnson JD, Kuftinec MM. Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation and sulcular bleeding during orthodontic treatment. Am J. Ortho Dentofac Orthop. 1989; 96(3): 199-207.
3. Vlachojannis C, Magora F, Chrubasik S. Review: Rise and fall of oral health products with Canadian bloodroot extract. Phytother Res. 2012: 26: 1423-1426.
4. Bloodroot (Sanguinaria canadensis). In: Natural Standard [Internet Database]. Somerville, MA: Natural Standard. Updated Periodically. Retrieved on July 3, 2013 from: http://www.naturalstandard.com.proxy.lib.uwaterloo.ca/databases/herbssupplements/bloodroot.asp?
5. Bloodroot IN: Micromedex 2.0 [Internet Resource]. Last update 2002. Retrieved on July 3, 2013 from: http://www.micromedexsolutions.com/micromedex2/librarian/ND_T/evidencexpert/ND_PR/evidencexpert/CS/FA0CE7/ND_AppProduct/evidencexpert/DUPLICATIONSHIELDSYNC/B49BD0/ND_PG/evidencexpert/ND_B/evidencexpert/ND_P/evidencexpert/PFActionId/evidencexpert.DisplayAltMedEvalDocument?docId=113&contentSetId=60&title=BLOODROOT&servicesTitle=BLOODROOT
6. Bloodroot (Natural Products Database) In: Lexicomp [Internet Resource]. Retrieved on July 3, 2013 from http://online.lexi.com.proxy.lib.uwaterloo.ca/lco/action/doc/retrieve/docid/fc_rnp2/3750055