Polyethylene glycol 400, propylene glycol, Hp-guar
Place in Therapy
Place in Therapy
Systane Lubricant Eye Drops is an appropriate option for sporadic or chronic treatment (instil 1 drop in both eyes five times daily) of dry eye. Since Systane Lubricant Eye Drops contains Polyquad, albeit a less toxic preservative, it is not appropriate for patients who require preservative free formulations.1
Systane (HP-guar) has demonstrated statistically significant improvements in tear break-up time (TBUT) compared to: Visine Intensive 1% EDO (TSP), p = 0.021; carboxymethylcellulose-based solution (Refresh Tears), p < 0.0014; and glycerin/polysorbate 80-based solution (Refresh Endura), p = 0.033.4 Furthermore Systane (HP-guar) has demonstrated statistically significant improvements in subjective measures such as foreign body sensation, compared to Refresh Tears (p = 0.033).4,5 Also, Systane (HP-guar) has demonstrated statistically significant improvements in subjective measures of morning dryness and end of day dryness, compared to Refresh Tears (p = 0.033 and p = 0.037 respectively).4,5
References:
1. Jacobi C, Kruse FE, Cursiefen C. Prospective, randomized, controlled comparison of Systane UD eye drops versus Visine Intensiv 1% EDO eye drops for the treatment of moderate dry eye. J Ocul Pharmacol Th. 2012; 28: 598-603
2. Conjunctivochalasis (CCh). The Ocular Surface Research & Education Foundation (OSREF) website. http://www.osref.org/medical-education-materials/conjunctivochalasis.aspx. Published n.d. Updated n.d. Accessed March 9, 2014.
3. How Systane Works. Systane Healthcare Professionals website. http://www.systane.ca/ca_en/professional/Systane_MOA.asp. Published 2004. Updated n.d. Accessed March 9, 2014.
4. Mussoline JF. Systane for dry eye. Cataract & Refractive Surgery Today. August 2004:88-89
5. Study Summary. Systane Healthcare Professionals website. http://www.systane.ca/ca_en/professional/evaluation_HPGuar.asp. Published 2004. Updated n.d. Accessed March 9, 2014.
6. Foulks GN. 2007 report of the International Dry Eye Workshop (DEWS). TOS. 2007; 5: 65-204
Systane Lubricant Eye Drops is an appropriate option for sporadic or chronic treatment (instil 1 drop in both eyes five times daily) of dry eye. Since Systane Lubricant Eye Drops contains Polyquad, albeit a less toxic preservative, it is not appropriate for patients who require preservative free formulations.1
Systane (HP-guar) has demonstrated statistically significant improvements in tear break-up time (TBUT) compared to: Visine Intensive 1% EDO (TSP), p = 0.021; carboxymethylcellulose-based solution (Refresh Tears), p < 0.0014; and glycerin/polysorbate 80-based solution (Refresh Endura), p = 0.033.4 Furthermore Systane (HP-guar) has demonstrated statistically significant improvements in subjective measures such as foreign body sensation, compared to Refresh Tears (p = 0.033).4,5 Also, Systane (HP-guar) has demonstrated statistically significant improvements in subjective measures of morning dryness and end of day dryness, compared to Refresh Tears (p = 0.033 and p = 0.037 respectively).4,5
References:
1. Jacobi C, Kruse FE, Cursiefen C. Prospective, randomized, controlled comparison of Systane UD eye drops versus Visine Intensiv 1% EDO eye drops for the treatment of moderate dry eye. J Ocul Pharmacol Th. 2012; 28: 598-603
2. Conjunctivochalasis (CCh). The Ocular Surface Research & Education Foundation (OSREF) website. http://www.osref.org/medical-education-materials/conjunctivochalasis.aspx. Published n.d. Updated n.d. Accessed March 9, 2014.
3. How Systane Works. Systane Healthcare Professionals website. http://www.systane.ca/ca_en/professional/Systane_MOA.asp. Published 2004. Updated n.d. Accessed March 9, 2014.
4. Mussoline JF. Systane for dry eye. Cataract & Refractive Surgery Today. August 2004:88-89
5. Study Summary. Systane Healthcare Professionals website. http://www.systane.ca/ca_en/professional/evaluation_HPGuar.asp. Published 2004. Updated n.d. Accessed March 9, 2014.
6. Foulks GN. 2007 report of the International Dry Eye Workshop (DEWS). TOS. 2007; 5: 65-204