Moi-stir
Place in Therapy
Place in Therapy
Moi Stir is a saliva substitute that contains carboxymethylcellulose (CMC). It is mainly used to temporarily relieve xerostomia. Moi-Stir has been studied in the context of patients’ with xerostomia from cancer treatment, Sjögren’s syndrome, HIV/AIDS, aging, concurrent medications, and other medical conditions1. It may be effective in increasing salivary flow rate and preferred over other saliva substitutes, but there seems to be no significant difference in efficacy or preference compared to other saliva substitute products2. Most of the studies were done at least 10 years ago and they seemed to have flaws that prevent the results to be significant. The evidence for safety and toxicity profile of Moi-stir is lacking, but the caution is required in lactating and pregnant individuals, individuals hypersensitive to CMC or parabens, or those with hypertension or renal failure3.
References:
1. Visch L, Gravenmade E, Schaub R, et al. A Double-blind Crossover Trial of CMC- and Mucin-containing Saliva Substitutes. Int. J. Oral Maxillofac. Surg. 1986: 15: 395—400
2. Björnström M, Axéll T, Birkhed D. Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study. Swed Dent J. 1990; 14(4):153-61
3. Karch AM. 2013 Lippincott's Nursing Drug Guide. 2013 ed. Ambler, PA: Lippincott Williams & Wilkins; June 11th, 2012.
Moi Stir is a saliva substitute that contains carboxymethylcellulose (CMC). It is mainly used to temporarily relieve xerostomia. Moi-Stir has been studied in the context of patients’ with xerostomia from cancer treatment, Sjögren’s syndrome, HIV/AIDS, aging, concurrent medications, and other medical conditions1. It may be effective in increasing salivary flow rate and preferred over other saliva substitutes, but there seems to be no significant difference in efficacy or preference compared to other saliva substitute products2. Most of the studies were done at least 10 years ago and they seemed to have flaws that prevent the results to be significant. The evidence for safety and toxicity profile of Moi-stir is lacking, but the caution is required in lactating and pregnant individuals, individuals hypersensitive to CMC or parabens, or those with hypertension or renal failure3.
References:
1. Visch L, Gravenmade E, Schaub R, et al. A Double-blind Crossover Trial of CMC- and Mucin-containing Saliva Substitutes. Int. J. Oral Maxillofac. Surg. 1986: 15: 395—400
2. Björnström M, Axéll T, Birkhed D. Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study. Swed Dent J. 1990; 14(4):153-61
3. Karch AM. 2013 Lippincott's Nursing Drug Guide. 2013 ed. Ambler, PA: Lippincott Williams & Wilkins; June 11th, 2012.